Cyactiv® Flex of Cerule

Healthy joints are essential for comfortable and effortless movement. They constitute the master piece of body mobility. A nutritional support can be helpful to protect and maintain joint function. Cyactiv® Flex is a natural and innovative solution composed of clinically proven and standardized extracts. Cyactiv® Flex is specifically formulated to support joint comfort and a healthy physical activity.

PRODUCT LABEL

What is the function of Cyactiv® Flex? Specifically designed with natural ingredients standardized in active molecules, Cyactiv® Flex is a food supplement that supports joint comfort and physical activity. Can Cyactiv® Flex be consumed with other Cerule products and other nutrients ? Yes, the Cerule products can be consumed together and were designed to enhance the beneficial effects of each other. We know of no known interaction between Cerule products and other nutritional supplements. Cyactiv® Flex is a food supplement which is not intended to treat, diagnose or prevent any disease.

CONDITIONS OF USE

Recommended daily dose: 2 capsules, 2 times per day, with a glass of water, during meals. Do not refrigerate.

ADDITIONAL INFORMATION

Do not contain dairy products, wheat, nuts, soy and corn. Do not contain artificial aroma, preservative or coloring agent. Capsule exclusively composed of ingredient of vegetal origin. Suitable for vegetarian consumers. Contains egg derived product. Pregnancy and nursing are considered special conditions. We recommend that your attending doctor(s) be made aware of any and all supplements consumed during this time. At this time, we do not advise Cyactiv® Flex consumption during pregnancy. If you have any health condition and/or are using any medication then consult your attending health care provider before consuming any nutritional supplement. Food supplements cannot be substitutes for a varied and balanced diet and a healthy lifestyle.

CYACTIV® FLEX. NATURAL AND INNOVATIVE FORMULA SUPPORTING JOINT COMFORT, COMPOSED OF CLINICALLY TESTED INGREDIENT

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REFERENCES

Spirulina extract

Jensen G., Attridge V., Beaman J., Guthrie J., Ehmann A., Benson K., 2015, Antioxidant and anti-inflammatory properties of an aqueous cyanophyta extract derived from Arthrospira platensis: contribution to bioactivities by the non-phycocyanin aqueous fraction, Journal of Medicinal Food, 18(5):535-541. Jensen G., Attridge V., Carter S., Guthrie J., Ehmann A., Benson K., 2016, Consumption of an aqueous cyanophyta extract derived from Arthrospira platensis is associated with reduction of chronic pain: results from two human clinical pilot studies, Nutrition and Dietary Supplements, 8:65-70. Jensen G., Drapeau C., Lenninger M., Benson K., 2016, Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation, Journal of Medicinal Food, 19(7): 1-9. Egg shell membrane Benson K., Ruff K., Jensen G., 2012, Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor-a Levels After In Vitro Digestion, J Med Food 15 (4) 2012, 360–368 Ruff K., DeVore D., Leu M., Robinson M., 2009,

Eggshell membrane:

A possible new natural therapeutic for joint and connective tissue disorders. Results from two openlabel human clinical studies, Clinical Interventions in Aging 2009:4 235–240. Danesch U., Seybold M., et al., 2014, NEM® Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study, J Arthritis, 3(3):1-5. Ruff K., Winkler A., Jackson R. et al., 2009, Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebocontrolled clinical study, Clin Rheumatol, 28:907–914.

Tart Cherry powder:

Connolly D., McHugh M., Padilla-Zakour O., 2006, Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage, Br J Sports Med 2006;40:679–683. Levers K., Dalton R., Galvan E., O’Connor A., et al., 2016, Effects of powdered Montmorency tart cherry supplementation on acute endurance exercise performance in aerobically trained individuals, Journal of the International Society of Sports Nutrition, 13:22

Boswellia serrata extract

Kimmatkar N., Thawani V., Hingorani L., Khiyani R., 2003, Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee- -a randomized double blind placebo controlled trial, Phytomedicine, 10(1):3-7 Prabhavathi K., Chandra U., Soanker R., Rani P., 2014, A randomized, double blind, placebo controlled, cross over study to evaluate the analgesic activity of Boswellia serrata in healthy volunteers using mechanical pain model, Indian J. Pharmacol, 46(5):475-479. Umar S., Umar K., Sarwar A., et al., 2014, Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis, Phytomedicine, 21(6):847- 56.